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KMID : 0043320100330060797
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Archives of Pharmacal Research
2010 Volume.33 No. 6 p.797 ~ p.805
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Synthesis and Anti-Hepatitis B Activity of New Substituted Uracil and Thiouracil Glycosides
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Mohammed T. Abdel-Aal
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Abstract
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A number of N- and S-substituted uracil and thiouracil glycosides were synthesized by coupling reaction of 5,6-dibenzyle pyrimidine derivatives with the corresponding acetobromosugar. The synthesized compounds were tested for their antiviral activity against hepatitis B virus. Plaque reduction infectivity assay was used to determine virus count reduction as a result of treatment with tested compounds which showed moderate to high antiviral activities.
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KEYWORD
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Pyrimidines, Glycosides, Thioglycosides, Antiviral activity
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